Coach and Russell & Bromley will open stores on the Upper East Mall alongside the likes of Michael Kors, Whistles, Ted Baker and Diesel.
A Ben Sherman store is also set to open at the recently developed LinkStreet mall.
Coach, the New York design house of modern luxury accessories for women and men, will open its first standalone store in the region.
The 280sq m space will offer the brand’s full range of bags, footwear, outerwear and accessories.
British footwear brand Russell & Bromley will join Coach on the centre’s Upper East Mall later in the year, in a 260sq m store.
The iconic Ben Sherman brand is set to open on 10 April in a 164sq m store on the LinkStreet mall area, which is located on the walkway between the Bullring and Grand Central.
Offering its full range of menswear collections including shoes and accessories, the store joins the likes of Luke 1977 and Pretty Green in taking a unit at LinkStreet.
Other brands to join the new revamped mall space include the hugely popular restaurants, Not Dogs and Cereal Killer Café.
Michaela Moore, Bullring general manager, said: “It’s fantastic news not just for Bullring but for the city that these three stand-out brands have decided to have a presence in Birmingham.
“All three brands follow Smashbox, T2 and New Look Men in choosing the centre to open their first standalone stores in the region.”